Tuesday, March 28, 2017

Tranexamic acid, the accidental wonder agent for melesma : take care in areas of polycythemia vera

Careful screening for personal and familial risk factors for thromboembolism should be done before initiation of oral tranexamine therapy* for chronic,refractory melesma in Asian populations.

The Himalayan regions of India and Nepal have a high incidence of polycythemia vera and one should always take this into consideration before prescribing the medication.
The other factors one takes into consideration before resorting to this therapy  are the number of unwanted side effects of the drug like nausea,diarrhoea and abdominal pain. Hypomenorrhoea is also a common side effect.

Although tranexamic acid does have tyrosinase inhibitory properties and is useful for refractory melesma, my personal preference for melesma therapy would be the newer,powerful and safer tyrosinase inhibitors which give good results over time and no side effects.
This is the basis of my skin care series in smilemakernyc.com where none of our skin care products  have side effects;no complaints from any client since we launched  it about a year and 4 months ago.

Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis.

Lee HCThng TGGoh CL 2016 Aug;75(2):385-92. doi: 10.1016/j.jaad.2016.03.001. Epub 2016 May 17.

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